Lipiodol® Ultra Fluid – Bibliography

The only oil-based contrast agent indicated for HSG

(1) Lindequist S et al. Diagnostic quality and complications of hysterosalpingography: oil- versus water-soluble contrast media-a randomized prospective study. Radiology. 1991 Apr;179(1):69-74.

(2) Nunley WC Jr et al. Intravasation during hysterosalpingography using oil-base contrast medium–a second look. Obstet Gynecol. 1987 Sep;70(3 Pt 1):309-12.

(3) Johnson NP et al. The FLUSH trial–flushing with lipiodol for unexplained (and endometriosis-related) subfertility by hysterosalpingography: a randomized trial. Hum Reprod. 2004 Sep;19(9):2043-51.

(4) Johnson NP et al. Lipiodol fertility enhancement: two-year follow-up of a randomized trial suggests a transient benefit in endometriosis, but a sustained benefit in unexplained infertility. Hum Reprod. 2007 Nov;22(11):2857-62.

(5) Brent K et al. After the FLUSH trial: A prospective observational study of lipiodol flushing as an innovative treatment for unexplained and endometriosis-related infertility. Aust N Z J Obstet Gynaecol. 2006 Aug;46(4):293-7.

(6) Mohiyiddeen L et al. Tubal flushing for subfertility. Cochrane Database Syst Rev. 2015 May 1;(5):CD003718.

(7) Dreyer K et al. Oil-based or water-based contrast for hysterosalpingography in infertile women. N Engl J Med. 2017 May 25;376(21):2043-52.

(8) Izumi G et al. Oil-Soluble Contrast Medium (OSCM) for hysterosalpingography modulates dendritic cell and regulatory T cell profiles in the peritoneal cavity: a possible mechanism by which OSCM enhances fertility. J Immunol. 2017 Jun 1;198(11):4277-84.

(9) Decision Resources Group. AMR Imaging database. 2017.

(10) American College of Radiology. ACR Practice parameter for the performance of hysterosalpingography. 2014.

(11) Collège National des Gynécologues et Obstétriciens Français (CNGOF):

(12) Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile female: a committee opinion. Fertil Steril. 2015 Jun;103(6):e44-50.

(13) Canadian Fertility & Andrology Society. CFAS consensus document for the investigation of infertility by first line physicians. Aug 2002.

(14) National Institute for Health and Clinical Excellence (NICE): guidance. Fertility: assessment and treatment for people with fertility problems. Feb 2013. Ref: 213280.

(15) Lindequist S et al. Use of iotrolan versus ethiodized poppy-seed oil in hysterosalpingography. Radiology. 1994 May;191(2):513-7.

(16) de Boer AD et al. Oil or aqueous contrast media for hysterosalpingography: a prospective, randomized, clinical study. Eur J Obstet Gynecol Reprod Biol. 1988 May;28(1):65-8.

(17) Fang F et al. Oil-based versus water-based contrast for hysterosalpingography in infertile women: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2018 Jul 1;110(1):153-160.e3.


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